BCH 5413 Mammalian Molecular Biology and Genetics 3 Credits

Grading Scheme: Letter Grade

Biochemical and genetic approaches to understanding vertebrate and particularly mammalian molecular biology, moving from basic processes of replication, transcription, and protein synthesis to signal transduction, cell cycle, cancer, genomics, and developmental genetics.

Prerequisite: BCH 3025, 4014, CHM 3218, 4207, MCB 4303, or PCB 3063 or consent of instructor.

Catalog Program Pages Referencing BCH 5413

BCH 6040 Research Discussion in Biochemistry and Molecular Biology 1 Credit

Grading Scheme: S/U

Current research in biochemistry and molecular biology will be presented by departmental faculty and invited speakers.

Prerequisite: Required as students in Biochemistry and Molecular Biology. Open to students in other fields with permission of the instructor.

Catalog Program Pages Referencing BCH 6040

BCH 6206 Advanced Metabolism 3 Credits

Grading Scheme: Letter Grade

Reactions of intermediary metabolism, emphasizing their integrations, mechanisms, and control. Extensive examples from current literature.

Prerequisite: BCH 4024, CHM 4207, or consent of instructor. One of three core biochemistry courses.

Catalog Program Pages Referencing BCH 6206

BCH 6207 Advanced Metabolism: Role of Membranes in Signal Transduction and Metabolic Control 1 Credit

Grading Scheme: Letter Grade

Fundamentals of membrane biochemistry. Discussions of membrane structure, nutrient and ion transport, protein targeting, and signal transduction. Experimental methods and techniques used to gather and analyze data related to membrane biochemistry and its regulation.

Prerequisite: BCH 3025, 4024, CHM 3218, 4207, GMS 6001, or consent of instructor.

Catalog Program Pages Referencing BCH 6207

BCH 6208 Advanced Metabolism: Regulation of Key Reactions in Carbohydrate and Lipid Metabolism 1 Credit

Grading Scheme: Letter Grade

Key reactions in metabolic pathways of carbohydrate and lipid metabolism. Explores the experimental basis for current understanding of these processes. Understanding the interactions between major metabolic pathways and control of these pathways under different physiological conditions.

Prerequisite: BCH 3025, 4024, CHM 3218, 4207, GMS 6001, or consent of instructor.

Catalog Program Pages Referencing BCH 6208

BCH 6209 Advanced Metabolism: Regulation of Key Reactions in Amino Acid and Nucleotide Metabolism 1 Credit

Grading Scheme: Letter Grade

Understanding interactions among major metabolic pathways and control of these pathways under different physiological conditions. Structural basis of enzyme function and regulation.

Prerequisite: BCH 3025, 4024, CHM 3218, 4207, GMS 6001, or consent of instructor.

Catalog Program Pages Referencing BCH 6209

BCH 6415 Advanced Molecular and Cell Biology 3 Credits

Grading Scheme: Letter Grade

Molecular biology of pro- and eukaryotic organisms. Emphasizes understanding the experimental approaches that led to recent developments. Chromosome structure and organization, advances in recombinant DNA technology, DNA replication, RNA transcription and protein synthesis, and selected aspects of molecular regulation of gene expression.

Prerequisite: BCH 4024, CHM 4207, MCB 4303, or consent of instructor. PCB 3063 or a similar course in genetics recommended. One of three core biochemistry courses.

Catalog Program Pages Referencing BCH 6415

BCH 6740 Physical Biochemistry/Structural Biology 3 Credits

Grading Scheme: Letter Grade

Physical chemistry of biological molecules and techniques to study their properties. Approaches to structure determination.

Prerequisite: BCH 4024, CHM 4207, or consent of instructor. Course in physical chemistry recommended. One of three core biochemistry courses.

Catalog Program Pages Referencing BCH 6740

BCH 6741C Magnetic Resonance Imaging and Spectroscopy in Living Systems 1-3 Credits

Grading Scheme: Letter Grade

MR imaging methods used to study the structure of cells, tissues, and whole animals. MR spectroscopy methods for monitoring biochemistry in living animals. Preparing samples, operating the instruments, and analyzing the data.

Prerequisite: BCH 6740 or equivalent or consent of instructor.

BCH 6744 Molecular Structure Determination by X-ray Crystallography 1 Credit

Grading Scheme: Letter Grade

Detailed theoretical and practical instruction on technique of x-ray crystallography used for three-dimensional structure determination of macromolecules in studies aimed at structure-function elucidation.

Prerequisite: BCH 6740 or equivalent or consent of instructor.

Catalog Program Pages Referencing BCH 6744

BCH 6744L Molecular Structure Determination by X-Ray Crystallography Laboratory 1 Credit

Grading Scheme: Letter Grade

Complement to BCH 744 lectures. Practical experience in sample preparation, operation of instrumentation, data acquisition analysis, phasing and refinement. Hands-on approach reinforces applicability of this methodology in analysis of functional properties of biological macromolecule.

Prerequisite: or coreq: BCH 6744: Molecular Structure Determination by X-ray Crystallography . ;

Corequisite: Coreq:

BCH 6745 Molecular Structure and Dynamics of NMR Spectroscopy 1 Credit

Grading Scheme: Letter Grade

Theoretical and practical introduction to macromolecular NMR spectroscopy. Basics of multidimensional NMR for structure and dynamics measurements. Hands-on training in modern NMR.

Prerequisite: BCH 6740 or equivalent or consent of instructor.

Catalog Program Pages Referencing BCH 6745

BCH 6745L Molecular Structure and Dynamics by NMR Spectroscopy Laboratory 1 Credit

Grading Scheme: Letter Grade

Complement to BCH 6745 lectures. Emphasizes practical applications of molecular structure and dynamics determination. Extensive use of computer software packages. Training in modern NMR instrumentation, data processing, and data analysis. Completed training sufficient for use of NMR instrumentation in Advanced Magnetic Resonance Imaging and Spectroscopy facility.

Prerequisite: or coreq: BCH 6745.

Corequisite: undefined

BCH 6746 Structural Biology: Macromolecular Structure Determination 1 Credit

Grading Scheme: Letter Grade

Experimental approaches to biological macromolecular structure determination. Emphasizes current understanding of protein-protein and protein-nucleic acid structure motifs.

Prerequisite: BCH 3025, 4024, CHM 3218, 4207, GMS 6001 or consent of instructor.

Catalog Program Pages Referencing BCH 6746

BCH 6747 Structural Biology/Advanced Physical Biochemistry: Spectroscopy and Hydrodynamics 1 Credit

Grading Scheme: Letter Grade

Applying spectroscopic techniques (circular dichroism, fluorescence, nuclear magnetic resonance) to determine the structure of biological macromolecules. Hydrodynamic approaches including light scattering, molecular diffusion, viscosity, and ultracentrifugation.

Prerequisite: BCH 3025, 4024, CHM 3218, 4207, GMS 6001, or consent of instructor.

Catalog Program Pages Referencing BCH 6747

BCH 6749C Numerical Methods in Structural Biology 1 Credit

Grading Scheme: Letter Grade

Introduction to mathematical and computational methods needed to understand current structural models, biophysical processes, data acquisition methods, and analysis of data acquired with current techniques.

Prerequisite: BCH 6740 or equivalent or consent of instructor.

BCH 6875 Crystallography and Cryo-Electron Microscopy 1 Credit, Max 4 Credits

Grading Scheme: S/U

Journal club covering current literature on methodologies, applications, and discoveries in crystallography and cryo-electron miscroscopy.

Prerequisite: BCH 6740 or equivalent, or consent of instructor.

Catalog Program Pages Referencing BCH 6875

BCH 6876 Recent Advances in Membrane Biology 1 Credit

Grading Scheme: S/U

Literature presented by students and faculty, discussed in depth. Emphasizes current developments, data, interpretation, and critical analysis.

Prerequisite: general biochemistry or consent of instructor.

Catalog Program Pages Referencing BCH 6876

BCH 6877 Recent Advances in Structural Biology 1 Credit, Max 8 Credits

Grading Scheme: S/U

Literature on structural biology presented by students and faculty, discussed in depth. Current developments, data interpretation, and critical analysis.

Prerequisite: general biochemistry or consent of instructor.

Catalog Program Pages Referencing BCH 6877

BCH 6905 Independent Studies in Biochemistry and Molecular Biology 1-5 Credits, Max 12 Credits

Grading Scheme: Letter Grade

Individual literature-based or experimental research problem.

Prerequisite: permission of instructor.

Catalog Program Pages Referencing BCH 6905

BCH 6910 Supervised Research 1-5 Credits, Max 5 Credits

Grading Scheme: S/U

Supervised Research

Prerequisite: consent of instructor.

Catalog Program Pages Referencing BCH 6910

BCH 6936 Biochemistry Seminar 1 Credit, Max 20 Credits

Grading Scheme: Letter Grade

Research reports and discussions of current research literature given by graduate students, departmental faculty, and invited speakers.

Prerequisite: required of graduate students in biochemistry; open to others by special arrangement.

Catalog Program Pages Referencing BCH 6936

BCH 6971 Research for Master's Thesis 1-15 Credits

Grading Scheme: S/U

Research for Master's Thesis

Prerequisite: consent of instructor.

Catalog Program Pages Referencing BCH 6971

BCH 7410 Advanced Gene Regulation 1 Credit, Max 3 Credits

Grading Scheme: Letter Grade

Literature-based assessment of the most recent advances in factors governing eukaryotic gene regulation.

Prerequisite: GMS 6001 or consent of instructor.

Catalog Program Pages Referencing BCH 7410

BCH 7412 Epigenetics of Human Disease and Development 1 Credit

Grading Scheme: Letter Grade

BCH 6415 recommended. In-depth assessment of epigenetic mechanisms of mammalian gene regulation: DNA methylation, histone modifications, genomic imprinting, inherited genetic diseases, viral gene regulation, and epigenetic reprogramming in embryonic stem cells and cloning.

Prerequisite: GMS 6001.

Catalog Program Pages Referencing BCH 7412

BCH 7414 Advanced Chromatin Structure 1 Credit

Grading Scheme: Letter Grade

Lecture and literature-based assessment of chromatin structure.

Prerequisite: BCH 5413, GMS 6001, or consent of instructor.

Catalog Program Pages Referencing BCH 7414

BCH 7515 Structural Biology/Advanced Physical Biochemistry: Kinetics and Thermodynamics 1 Credit

Grading Scheme: Letter Grade

Fundamentals of chemical kinetics and thermodynamic analysis of equilibria. Emphasizes applying this knowledge to understand basic enzyme kinetics, pulse-chase kinetics, protein polymerization, DNA dynamics, protein-nucleic acid interactions, and cooperative ligand binding.

Prerequisite: BCH 4024, CHM 3218, 4207, GMS 6001, or consent of instructor.

Catalog Program Pages Referencing BCH 7515

GMS 5905 Special Topics in Biomedical Sciences 1-4 Credits, Max 4 Credits

Grading Scheme: Letter Grade

Analysis and discussion of contemporary topics and the development of biomedical sciences.

Catalog Program Pages Referencing GMS 5905